Formerly known as HIV Meds Quarterly, this series of updates provides brief reports and analysis of new findings related to common therapies used by HIV clinicians.

Susa Coffey, MD, Medical Editor
AETC National Resource Center

Ian R. McNicholl, PharmD, BCPS (Added Qualifications-Infectious Diseases), Pharmacy Editor
AETC National Resource Center

Darunavir Once-Daily Dosing for Children

Tenofovir alafenamide fumarate (TAF) is an investigational prodrug of tenofovir. You will recall that the current tenofovir product, tenofovir disoproxil fumarate (TDF), also is a prodrug; so why are we interested in a new prodrug? This largely has to do with efforts to decrease the toxicity associated with tenofovir.

The investigational integrase inhibitor dolutegravir has been studied in treatment-naive patients and in treatment-experienced patients with integrase inhibitor-associated resistance. The present study (SAILING) evaluates dolutegravir in 715 patients who